Home › Venues › Route 66 Hotel and Conference Center Route 66 Hotel and Conference Center Tickets Buy tickets for concerts at Route 66 Hotel and Conference Center in Springfield, IL. No Upcoming Events No upcoming events scheduled at Route 66 Hotel and Conference Center. Please contact us with any corrections. Hotels & Lodging Near Route 66 Hotel and Conference Center About the Venue Route 66 Hotel and Conference Center At-a-Glance Address625 E Saint JosephSpringfield, IL 62703United States Map & Directions Advertisement