In the early 1990s, Moore helped found the New Orleans-based essential funk band Galactic. Their first album, 1996's widely acclaimed "Coolin' Off," led to an intense tour schedule of nearly 200 gigs a year for the next decade. Building on their fanbase by adding an esteemed list of all-star collaborations to the six albums that followed, Galactic continues to amass a worldwide audience via recording and touring globally.

Moore launched his solo career in 1998 aided by eight-string guitar virtuoso Charlie Hunter and saxophonist Skerik (Les Claypool, John Scofield, Roger Waters). The group recorded "All Kooked Out!," featuring a handful of local New Orleans musicians as well. In the midst of these recording sessions yet another concept was taking shape. Outtakes turned into the first Garage a Trois release, "Mysteryfunk" (1999). In 2000 the trio, led by Moore behind the drums, was joined by percussionist Mike Dillon (Les Claypool, Ani DiFranco) and has since released three more albums: "Emphasizer" in 2003, "Outre Mer" in 2005, and "Power Patriot" in 2009.

Moore extended his solo discography with the release of "Flyin' the Koop" (Verve/Blue Thumb) in 2001, and "III" in 2006. Following the latter, Modern Drummer magazine called Moore's trademark sound "infectious, jazz-meets-Bonham, nouveau second-line. " Recorded at the legendary Preservation Hall in New Orleans, III featured organist Robert Walter (Greyboy Allstars, The Head Hunters) and guitarist Will Bernard (T. J. Kirk, Doctor Lonnie Smith) as the Stanton Moore Trio, with special guests Skerik and trombonist Mark Mullins (Galactic, Bonerama, Harry Connick, Jr., Better Than Ezra). In 2008, Moore looked to continue his scaled-back session crew with Walter and Bernard to record "Emphasis!" (on parenthesis).

"Groove Alchemy" was released in 2010. The 12-track set serves as the culmination of Moore's multimedia project that also includes an instructional book and DVD of the same name. All three facets of the project are designed to explore the roots of funk drumming by examining the work of pioneers like Jabo Starks, Clyde Stubblefield, and Zigaboo Modeliste – each of whom made their mark at different times throughout the 1960s as the engines driving James Brown's and the Meters' legendary rhythm sections.

Showing his outstanding versatility, Moore has appeared on Heavy Metal Grammy nominees Corrosion of Conformity's "In the Arms of God," Irma Thomas's "After the Rain" (winning a Grammy in the process), Robert Walter's "Super Heavy Organ," Tom Morello (Rage Against the Machine) and Boots Riley's (the Coup) "Street Sweeper Social Club," Will Bernard's "Blue Plate Special," Diane Birch's "Bible Belt," Alec Ounsworth's (Clap Your Hands Say Yeah) "Mo Beauty," and Joss Stone's "Colour Me Free!" He continues to play dates globally with an ever-evolving cast of musicians including John Scofield, Karl Denson, George Porter, Jr. and Leo Nocentelli (of the Meters), Charlie Hunter, Warren Haynes, John Medeski and Chris Wood (of Medeski, Martin and Wood), Donald Harrison, Jr., Dr. Lonnie Smith, Dr. John, Tab Benoit and Robert Walter (of the New Orleans Klezmer All-Stars and the Preservation Hall Jazz Band) - and that's just to name a few.

Deeply affected by Katrina and its aftermath, New Orleans' native son was quick to lend a hand by spearheaded the Tipitina's Music Workshop, free Sunday seminars that cater to children and a rotating cast of well-known professionals to promote the preservation of New Orleans music. He also set up the Staletta Fund, a scholarship started by he and his wife, Aletta, to help cover costs for aspiring students to attend jazz camps, auditions and further their education. Moore stays active as a spokesperson for the Gulf Restoration Network and is a regular proponent of and player with the Voice of the Wetlands All-Stars. Additionally he serves on the board of directors for the Roots of Music, a free music education and academic mentoring program founded by Derrick Tabb, drummer for Rebirth Brass Band and recent nominee for CNN's Heroes awards.