Building up a following in the late 1990s by touring with bands such as GWAR, Nile, Cradle of Filth and Candiria, God Forbid's first full album Reject the Sickness was released by 9 Volt Records in 1999. This album received heavy rotation from WSOU-FM in the New York City area and the band was subsequently signed to Century Media Records, releasing the album Determination in 2001. They played on the MTV2 Headbangers Ball tour with Shadows Fall and Lamb of God.
In 2004, they released Gone Forever, which along with a slot on Ozzfest's second-stage, increased their profile considerably. The next year, they released IV: Constitution of Treason, a concept album about the end of the world. It was their first album to enter the Billboard 200, debuting at number 118. In 2005 and 2006, they supported Trivium on their UK tour along with Mendeed and Bloodsimple. In late 2006 and early 2007, they headlined the Chains of Humanity tour.
In 2006, God Forbid's "To the Fallen Hero" won the Independent Music Award for Best Hard Rock/Heavy Metal Song. They released a DVD on June 10, 2008, and their fifth studio album, Earthsblood, was released on February 24, 2009, and landed at number 110 on the Billboard 200. God Forbid toured across the United States and Canada in the No Fear Energy Music Tour featuring Lamb of God and others in April.
March 2009, Dallas Coyle left the band. His replacement for the upcoming tour was named as former Darkest Hour guitarist Kris Norris. He was later replaced by Matt Wicklund. In July 2009, God Forbid participated in the Rockstar Mayhem Festival along with Trivium, Bullet for My Valentine, Cannibal Corpse, All That Remains, Slayer, Marilyn Manson and many others.
In April 2010, the band issued an update that they started work on a new album. The new album is titled Equilibrium and was released on March 26, 2012.