John Molo is the product of immigrants - he counts three grandparents who came to the United States from Ireland and one from the border of Switzerland and Austria which is where his surname comes from. Molo grew up and lived in Washington, D.C. but his oceanographer father became increasingly concerned about the safety of the inner city and moved the family to the suburbs of Langley Virginia where he went to high school at Langley High School in Mclean, Virginia .
Molo was a member of Bruce Hornsby and the Range when the band won the Grammy Award for Best New Artist of 1986. After the Range disbanded in 1990, Molo continued to collaborate and tour with Hornsby until 2000.
In May 2009, Molo joined the band Moonalice.