Born in Massachusetts, Tedeschi is an alum of Berklee College of Music and a master of contemporary blues guitar. In 1994, she formed the Susan Tedeschi Band and the group released their first album "Better Days" the following year. In 1997, Tedeschi signed to Tone-Cool records and released her second album, "Just Won't Burn" in 1998. The album went Gold in the USA and garnered her a Grammy nomination for 'Best New Artist'.
For the next few years she toured extensively and opened for such artists as John Mellencamp, B.B. King, the Allman Brothers Band. In 2001, she married Allman Brothers band member Derek Trucks. In 2002 she released the critically acclaimed and Grammy nominated album "Wait for Me". She gave birth to her first child, Charlie in 2002, and her second child, Sophia, in 2004.
In 2005, she left Tone-Cool, signed to Verve Forecast and released the album "Hope and Desire", which featured covers of songs by artists such as the Rolling Stones, Ray Charles, Bob Dylan and Aretha Franklin.
In 2008, Back To The River, Susan's most personal album to-date, was released. All but one song was penned / co-written by Tedeschi and the album garnered her a Grammy nomination for Best Contemporary Blues Album, (her 5th Grammy nomination).
Susan continues to manage a solo career, but is currently focused on a new band, The Derek Trucks and Susan Tedeschi Band.